Researchers from the University of Minnesota College of Pharmacy have provided the first evidence-based data on changes in drug metabolism in obese children as compared to healthy weight children.
The study, conducted by researchers from Department of Experimental and Clinical Pharmacy, has evaluated drug metabolism in 16 healthy weight children and 9 obese children.
It is known for years that drugs metabolize differently in obese adults as compared to healthy weight adults, but, there has been very little, if any, information available that specifically addresses the consequences of obesity on drug metabolism in children. Without this information, the ability to identify optimal drug dosing in children often relies on trial and error approaches.
In the study, researchers have examined drug metabolizing enzyme activity in healthy weight and obese children, age 6 to 10 years old. Specifically, they looked at how the children metabolized Caffeine and Dextromethorphan, a key ingredient in the cough suppressant Robitussin DM.
They found that obese children metabolized both drugs at different rates than healthy weight children.
This finding is the first of many steps in determining the overall effect of obesity on drug absorption, distribution, metabolism and elimination in children. ( Xagena )
Source: Federation of American Societies for Experimental Biology, 2010